Midfielder Wilshere is out for three weeks with an ankle injury, although Abou Diaby could travel after a calf problem and former Bayern forward Lukas Podolski has overcome a fitness concern.
Left-back Kieran Gibbs is available again after his thigh injury to ease Arsene Wenger's defensive concerns, with Sagna ruled out and Nacho Monreal ineligible.
Bayern forward Franck Ribery will miss the game at the Allianz Arena, while midfielder Bastian Schweinsteiger and defender Jerome Boateng are both suspended.
Former Chelsea winger Arjen Robben, meanwhile, was not involved at the weekend against Fortunate Dusseldorf because of a calf problem.
Bayern, though, have the likes of Brazilian Luiz Gustavo and Switzerland midfielder Xherdan Shaqiri ready to come in as Jupp Heynckes' side look to protect a 3-1 advantage from the first leg.
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